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Asymmetry of parietal interhemispheric connections in humans
Research Area: Clinical Science Year: 2011
Type of Publication: Article Keywords: Adult
Authors:
  • G. Koch
  • M. Cercignani
  • S. Bonni
  • V. Giacobbe
  • G. Bucchi
  • V. Versace
  • C. Caltagirone
  • M. Bozzali
 
Journal: J.Neurosci. Volume: 31
Number: 24 Pages: 8967-8975
Month: June
   
Note:
DA - 20110616 IS - 1529-2401 (Electronic) IS - 0270-6474 (Linking) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't SB - IM
Abstract:
Visuospatial abilities are preferentially mediated by the right hemisphere. Although this asymmetry of function is thought to be due to an unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate is still largely unknown. Here, using a method of trifocal transcranial magnetic stimulation, we show that the right, but not left, human posterior parietal cortex exerts a strong inhibitory activity over the contralateral homologous area by a short-latency connection. We also clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect
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