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Clinical Science

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Quantitative_MRI

 
 

CLINICAL SCIENCE: APPLICATIONS OF ADVANCED MR TECHNIQUES

 

Our research group focuses on the development and application of quantitative MR techniques to neurological and psychiatric conditions. The final goal is to increase comprehension of their patho-physiological mechanisms and clinical manifestations. We work on the definition and application of multiparametric MRI protocols developing ways of applying neuroimaging to clinical trials. Currently, our main research field is the study of neurodegenerative diseases.

Over the last few years, a number of quantitative structural and functional MR techniques [e.g. Diffusion tensor Imaging (DTI); Voxel based Morphometry (VBM); 1H-Spectroscopy, functional MRI (fMRI)] have been introduced in vivo each with a unique ability to characterize brain tissue characteristics and functions.

These techniques have been already successfully applied to patients suffering from several clinical conditions, producing indirect information on the presence and extent of brain tissue damage both, at a macro- and microscopic level. They represent powerful tools to investigate the patho-physiological mechanisms underlying neurological and psychiatric conditions, to monitor their clinical evolution and to test the effect of treatments potentially able to modify clinical course. The development and optimization of new non-conventional MR techniques is now focussed on obtaining quantitative measures applicable to individual patients, with the ability to contribute to diagnosis and prognosis.


  

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