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Functional brain changes in early Parkinson's disease during motor response and motor inhibition
Research Area: Clinical Science Year: 2011
Type of Publication: Article Keywords: Aged
  • F. Baglio
  • V. Blasi
  • A. Falini
  • E. Farina
  • F. Mantovani
  • F. Olivotto
  • G. Scotti
  • R. Nemni
  • M. Bozzali
Journal: Neurobiol.Aging Volume: 32
Number: 1 Pages: 115-124
Month: January
DA - 20101124 IS - 1558-1497 (Electronic) IS - 0197-4580 (Linking) LA - eng PT - Journal Article RN - 7782-44-7 (Oxygen) SB - IM
Motor impairment represents the main clinical feature of Parkinson's disease (PD). Cognitive deficits are also frequently observed in patients with PD, with a prominent involvement of executive functions and visuo-spatial abilities. We used event-related functional MRI (fMRI) and a paradigm based on visual attention and motor inhibition (Go/NoGO-task) to investigate brain activations in 13 patients with early PD in comparison with 11 healthy controls. The two groups did not report behavioural differences in task performance. During motor inhibition (NoGO-effect), PD patients compared to controls showed an increased activation in the prefrontal cortex and in the basal ganglia. They also showed a reduced and less coherent hemodynamic response in the occipital cortex. These results indicate that specific cortico-subcortical functional changes, involving not only the fronto-striatal network but also the temporal-occipital cortex, are already present in patients with early PD and no clinical evidence of cognitive impairment. We discuss our findings in terms of compensatory mechanisms (fronto-striatal changes) and preclinical signs of visuo-perceptual deficits and visual hallucinations
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